Design and Evaluation of Novel Ibuprofen Gel and Its Permeability Studes

The objects of this study were to develop the topical usage of ibuprofen gel and evaluate the permeability status of the prepared gel. Ibuprofen gel was prepared by incorporation of mustard oil and ethanol for improving the ibuprofen release in the topical preparation at different ratio low, medium and high concentration. In general marketed ibuprofen gel, ointment or creams contain ibuprofen alone but in our formulation ibuprofen added in ethanol along with mustard oil. It acts as a rubefacient and counter-irritant and better relief from body ache. Invitro permeability study was carried out for ibuprofen incorporated gel and drug content was estimated by UV-Spectroscopy. Batch III shown the maximum permeation when compare to the Batch I and Batch II. The percentage release of ibuprofen release for three batches of prepared gel was 84.5, 85.3, and 91 respectively. Key wards: Ibuprofen, Permeability, Gel, Mustard oil. INTRODUCTION Ibuprofen is a potent non-steroidal antiinflammatory drug for effective treatment of acute and chronic arthritic, body pain, and head ache etc., therefore most of the non-steroid research work focus on ibuprofen transdermal preparation, which prevent the oral side effect like gastric mucosal damage, may lead to ulcer formation in gastrointestinal track, renal failure and prolonged site of action (Agyralides, 2004; Al-Saidan, 2004). Compared to other NSAID marketed formulation, ibuprofen is poor in permeability and difficult to achieve the therapeutic concentration in blood plasma (Chang, 1997). The extensive studies of drug release have revealed that the active ingredients in gel based formulation are better percutaneous absorption than cream or ointment base. Ibuprofen may a chance to get Corresponding author C.Gopi E-mail: [email protected] precipitate due to poor permeability. In addition to this permeability problem of ibuprofen can be solved by mixing with high ethanol concentration up to 70% in the gel preparation. Generally gel based formulation hold more percentage of ethyl alcohol than ointments and creams, Krishniah et al., 2004 proved that transdermal drug containing up to 70% alcohol were reported no sigh of skin irritation produced when applied to human. Besides that addition of mustard increases the viscosity of the gel makes permeability faster in the topical skin due to the increase the occlusive nature of the prepared gel, it has anti-fungal, rubefacient and counter-irritant properties (Uzma sitara, 2008; Mohammed ali, 2008). The study reveals that mustard oil has antibacterial, anti microbial and anti inflammatory activity. Recently, so many topical ibuprofen gel, creams, ointment were introduced in different percentage of drug content (5%, 10%, and 15%) which gives the better release but our prepared ibuprofen gel releases rapidly because of presence of ethanol and mustard oil incorporation. IJB